|
KMID : 1225720150070030301
|
|
Allergy, Asthma & Immunology Research : AAIR
2015 Volume.7 No. 3 p.301 ~ p.303
|
|
|
Immunologic Evaluation of Patients with Cefotetan-Induced Anaphylaxis
|
|
Nam Young-Hee
Hwang Eui-Kyung
Ban Ga-Young
Jin Hyun-Jung
Yoo Hye-Soo
Shin Yoo-Seob
Ye Young-Min
Nahm Dong-Ho
Park Hae-Sim
Lee Soo-Keol
|
|
|
Abstract
|
|
|
|
Cefotetan is a commonly prescribed second-generation cephalosporin that acts against a wide range of bacteria. However, cefotetan-induced hypersensitivity has rarely been reported. We report 2 cases of cefotetan-induced anaphylaxis with immunologic evaluation. The first case was a 70-year-old asthmatic woman who had dyspnea and hypotension during administration of cefotetan, in which high serum-specific IgE to cefotetan-human serum albumin (HSA) conjugate was detected by enzyme-linked immunosorbent assay. The second case was a 63-year-old asthmatic woman who complained of chest tightness and dyspnea during cefotetan infusion, in which high serum-specific IgG1 and IgG4 with no serum specific IgE to cefotetan-HSA conjugate was detected. The basophil activation test using basophils from the patient showed a significant up-regulation of CD63 with the addition of anti-IgG4 antibody compared with that in non-atopic healthy controls. In conclusion, cefotetan can induce anaphylaxis, which may involve both IgE- and IgG4-mediated responses in the pathogenic mechanism.
|
|
|
KEYWORD
|
|
|
Anaphylaxis, cefotetan, specific IgE, specific IgG4
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|